Jurgen Klopp's side have enjoyed a successful spell following their return from the November international break, with five wins out of five in all competitions, with the latest coming in a late 1-0 win over Wolves at the weekend.
The Reds now turn their focus back to the Champions League as they make their first-ever visit of the San Siro, with the hosts in need of a victory if they are to reach the knockout stages of the competition.
Whilst Liverpool have already emphatically qualified for the last-16 as group winners, Milan start the evening in third place - level on points with Atletico and a point below Porto, who face each other in the other Group B clash on Tuesday night.
The two sides met at Anfield in the reverse fixture on the opening day, with skipper Jordan Henderson scoring the winner to give Liverpool a 3-2 win after going 2-1 down just before half-time.
With little riding on the game for the Reds, Klopp will need to ensure his side aren't susceptible to any form of complacency against a highly motivated Milan side. A win for the visitors would see them become the first English side to have a 100% record in the group stages of the competition.
Klopp told reporters to expect changes to his side after naming an unchanged eleven at the weekend, with the likes of Kostas Tsimikas, Divock Origi and Takumi Minamino, amongst others, likely to feature from the off.
A number of youngsters made the flight to Italy, including Tyler Morton, Conor Bradley, Elijah Dixon-Bonner and Harvey Davies, whilst senior stars Virgil van Dijk, Jordan Henderson, Thiago and Diogo Jota all stayed on Merseyside.
Updated: 18:45 (GMT)
AC Milan: Maignan, Kalulu, Tomori, Romagnoli, Hernandez, Kessie, Tonali, Messias, Diaz, Krunic, Ibrahimovic. Substitutes: Tatarusanu, Jungdal, Bennacer, Ballo, Florenzi, Maldini, Bakayoko, Gabbia, Saelemaekers.
Liverpool: Alisson, N. Williams, Phillips, Konate, Tsimikas, Morton, Oxlade-Chamberlain, Minamino, Salah, Origi, Mane. Substitutes: Kelleher, Davies, Fabinho, Keita, Gomez, Robertson, Matip, Dixon-Bonner, Alexander-Arnold, Norris, Woltman, Bradley.
UK and USA TV Streaming
AC Milan vs Liverpool is available to stream in the United Kingdom on BT Sport 2, which is available on Sky channel 414 and Virgin Media channel 528.
Supporters in the United States can watch live on Paramount+ at 15:00 (ET).
Worldwide TV Streams
For viewers across the world, please refer to the list below for channels showing the game worldwide.
620 Now, SportKlub 1 Serbia, RMC Sport 1, 102 (HD) mio Stadium, Skynet Sports 6, ESPN2 Andina, SPOTV ON, Viaplay Sweden, Viaplay Denmark, Now E, BesTV, Ssports Live, Sky Sport Uno, S Sport+, Flow Sports 1, beIN Sports HD 11, GO TV Anywhere, TV3+ HD, Setanta Sports Kazakhstan, Watch ESPN Brasil, beIN Sports Connect Indonesia, Now Player, Blue To Go Video Everywhere, Canal+ Sport 2 Afrique, Flow Sports App, Bongda TV, Spiler1, SBS Live, SCTV 17, Cytavision Sports HD, #Vamos, TV2 Sumo, RDS GO, Ziggo Sport 14, Sky Pacific, PPTV Sport China, SuperSport 3 Africa, DAZN, Astro Supersport, Digi Sport 4, Viasat Football HD, Star Sports Select HD1, Stod 2 Sport, Astro Go, SL2G, SportKlub 1 Slovenia, Viaplay Finland, Diema Sport 2, NTV+ Sport Online, beIN Sports 1 Thailand, DIGI GO, Cytavision Sports 3, ESPN Brasil, Idman TV, ESPN Play Sur, Guangdong Sports Channel, Optus Sport, Play Sports 1, TVPlay Sports, Eurosport Romania, Match TV Football 1, Sport TV2, TSN GO, Hotstar