The Reds return to domestic action against Marco Silva's side as they look for a victory in the 232nd Merseyside derby at Anfield.
Liverpool's local rivals sit in sixth place in the Premier League, whilst Liverpool will be looking to keep up with leaders Manchester City at the top of the table.
Klopp's side suffered a 2-1 defeat away to Paris Saint-Germain on Wednesday, but the boss insists they will be up for the derby no matter what happened at the Parc des Princes.
“Come on, it’s a derby, we don’t have to show a reaction," he told reporters after the game.
“If we won 5-0 (against PSG) it would be the same. This game is isolated from the season, it’s a derby, it’s at home.
“Everton are doing really well this season, they are a different cup of tea to the last three years. We have to be 100% spot on for a tough one.
“It’s not about showing a reaction, it’s about carrying on, go, go, go in the league, win your home games, win your away games, and that’s it.
”On Sunday we will be ready again. It’s not what I say here, it’s what we show there.”
It may mean that new arrivals Fabinho and Naby Keita - both who were on the bench - could start their first game together, although James Milner and Gini Wijnaldum will also be looking to retain their place in the starting eleven.