The Reds take on Jose Mourinho's side at Anfield on Sunday afternoon, with victory over their arch rivals seeing them go 19 points ahead of them.
Despite contrasting first halves to the season, any fixture against a Jose Mourinho side promises to be a cagey affair.
The Reds have often been frustrated against Mourinho, with the last two meetings at Anfield ending goalless, despite Liverpool being in a rich vein of form for both.
There have been reports that United are set to field Nemanja Matic, Ander Herrera and Marouane Fellaini at Anfield as they look for physical battle in midfield.
“I don't think Jose Mourinho ever has a lack of ambition,” Klopp told reporters when asked on Mourinho's defensive style.
“He just does what he thinks is right, and he's one of the most successful managers in the world.
“[Last season's game] was not a joy for us.”
However, Klopp insisted that the Reds must not rest on their laurels and "fight" for all three points against United.
“I don't know what other teams make of our situation. But we never thought before a game, because we have a few good results in the past at home, that it would be easy in the next game,” he said.
“That's not the mood you can win football games in. We have to be angry on Sunday and we will be.
“We fight for our points, we don't sort problems for others or whatever; we have our own problems and our own targets and we go for them.”
However, Liverpool will be able to call up on James Milner, who was also forced off the field in the closing stages of the win against Napoli.
The boss played down his current injury concerns: “It's our situation. I'm not sure, a crisis is – I think – if you feel it is a crisis. It's our situation.”
Liverpool vs Man United kicks off at 4pm on Sunday and you can keep up with all the drama from Anfield via LFC Globe's live match-day coverage.