Jurgen Klopp's side needed a point to guarantee Champions League football for next season, and in the end it was a convincing day for the Reds as they eased past Brighton.
Mohamed Salah opened the scoring 26 minutes in, netting a record-breaking 32nd goal in a single Premier League campaign.
The Egyptian attacker, who has had a sensational first season at Liverpool, overtakes Alan Shearer, Luis Suarez and Cristiano Ronaldo by beating the record, as he claimed the Golden Boot award.
A Dejan Lovren header just before half-time saw Liverpool double double their advantage. The Croatian's goal was then to in the second half by Dominic Solanke and Andrew Robertson, who both scored their first-ever Reds goal.
Jurgen Klopp's side conclude their season with being unbeaten at home in the league; for only the second time in the Premier League era.
All eyes will now turn to Ukraine as the Reds face Real Madrid in the Champions League final in Kiev on May 26.
Liverpool were not quite at their fluid best in the beginning, although they did have a couple of strong penalty appeals rejected by referee Kevin Friend.
One in particular, Shane Duffy's challenge on Salah inside the box, looked to have been a certain penalty. However, it looked only a matter of time before the Reds would begin to threaten more seriously.
Sadio Mane was kept out by goalkeeper Mathew Ryan, when it appeared a pass to Salah - who was positioned alongside him - looked to have been a better option.
It didn't take long for Salah to finally make a decisive mark on the game as he netted past Ryan following a clever Solanke through-ball.
Salah and Mane continued to threaten for the Reds, and created a chance for themselves that saw the Egyptian's close-range effort being clawed away, with Duffy recovering in time to clear the follow-up shot.
Georginio Wijnaldum fired straight at Ryan, as the Reds continued to waste golden opportunities. However the second goal did arrive before the break, as Andrew Robertson's perfect delivery was met by a smashing header in to the back of the net from Lovren.
The hosts continued to threaten in the second half, with Roberto Firmino and Virgil van Dijk both working Ryan, before Solanke's powerful strike into the roof of the net for his first goal this season, in his 26th appearance.
The Reds then cruised through the second-half, knowing the advantage and superiority they held in the game.
Adam Lallana made a return with 15 minutes left, following a six week spell on the sidelines after only briefing returning from a pervious injury.
Liverpool did conjure up a fourth goal however, as Robertson also scored his first goal for the club, a loose ball falling in his path to hammer past Ryan to finish a comfortable day's work for Liverpool.
Liverpool (4-2-3-1): Karius; Alexander-Arnold, Lovren, Van Dijk, Robertson; Henderson, Wijnaldum; Mane (Lallana 74'), Salah (Woodburn 84'), Firmino (Ings 83'); Solanke.
Brighton and Hove Albion (4-3-3): Ryan; Schelotto, Duffy (Goldson 71'), Dunk, Bong; Stephens, Kayal (Gross 57'), Propper; Knockaert, Locadia (Murray 57'), March.