James Milner is set to miss out on playing against former club Liverpool for Brighton.
Milner made over 330 appearances in eight years at Liverpool before joining Brighton in June.
But a muscular injury looks like costing Milner a Premier League reunion with Liverpool at the Amex Stadium on Sunday.
Brighton boss Roberto De Zerbi said at his pre-match press conference: “It is difficult for James.
“He didn't work with the group until yesterday. I don't know if it's the best solution to take a risk with him especially in this moment because of (Pervis) Estupinan's injury.”
Ecuador full-back Estupinan is expected to be out for a month after being injured in Brighton's 6-1 Premier League defeat at Aston Villa last weekend.
It was only the second time since sustaining a season-ending knee injury last March that Lamptey had played a full game.
De Zerbi said: “We have to see (on Sunday) about Lamptey. I don't want to take a risk because he could have a problem.
“The other players are good. We have to change some things from the Marseille game.
“I have to make a decision about the first XI – try to win the game.
“To lose players in this moment will be stupid. We are still in October and it will be a long season.
“We have to play four more games in Europa League and many games in the Premier League.”
Brighton are winless in three games, their longest run without victory since last October when De Zerbi's first five matches as Seagulls boss brought two draws and three defeats.
But Brighton have an excellent record against Liverpool in recent seasons.
The south-coast club have lost only one of the last seven meetings between the two clubs and beat Liverpool twice at the Amex Stadium last season, 3-0 in the Premier League and 2-1 in the FA Cup.