The Reds have a flawless record in Group D so far, having established a five-point lead in the table and victory against Atalanta would seal qualification to the knockout stages.
The highlight so far is undoubtedly their win over the Serie A side in their last outing, with Diogo Jota scoring his first Reds hat-trick in a commanding 5-0 victory.
The visitors will be seeking redemption at Anfield, but Klopp insists they remain a threat regardless of the previous result.
"Atalanta is a threat without a point to prove, to be honest, but of course. The night in Atalanta was a really special one," Klopp said.
"We played exceptionally well and pretty much [did] everything right in the right moment, in the right manner. So many things came together that we won that game the way we won it.
"But we are not only in the business since yesterday, so we know that this game has nothing to do with the game tomorrow night. That means we have to be ready again.
"Atalanta is a top team and with a special way to play. At Atalanta, we did really well and we have to do well again, otherwise we have massive problems.
"I expect problems, to be honest, in the game because it's always like this. But we try to work on solutions for the potential problems in the short period of time we have in our hands."
On Liverpool being on the brink of progression with two games to spare, Klopp said: "Yeah, but you can only play one game. We cannot play two or three games in one.
"I know, it's all clear, that's all on the table, we don't have to mention it. Everybody knows if we would win then some problems would be sorted, but that's not the reason.
"The reason is we have to play, we have to be ready to work really, really, really hard against them. This man-marking system is a tough one to play against, that's why they were so successful in the past.
"Yes, it didn't work out against us the last time but they will not change it and we have to do it in a similar way, like we did in the other game.
"But since then a lot of games were played, a lot of things happened since then. So, we will see who we can line up tomorrow night and then we try to make the best of the situation."
The boss didn't give anything away regarding the fitness of some of his key players, insisting he doesn't wish to provide his opposition with any information ahead of the fixture.
But the boss confirmed Mohamed Salah would return after he tested negative for coronavirus and returned to training on Monday.
Klopp also had encouraging words for striker Roberto Firmino, who he described as being vital to the "orchestra" of his squad.
Watch everything Klopp had to say in the video above, courtesy of Blood Red.