With Liverpool unbeaten so far this season, the hope will be they can keep up their momentum and, at the minimum, maintain the seven point lead over City.
Whilst it is still too early in the season for the game to be considered a 'title decider', manager Jurgen Klopp will know a favourable result would put his side in a fantastic position to start the year.
James Milner should be available for the clash, with the midfielder returning to training this week after a spell out with a hamstring injury.
The boss will have some big decisions to make with his tactics, particularly the formation and system of his midfield set-up.
The personnel used in the middle of the park will be down to the system Klopp chooses, with the boss capable of approaching the game in two different ways.
That would leave Xherdan Shaqiri or Naby Keita as the third midfielder, although this may represent an unnecessary defensive gamble in such a huge fixture.
Therefore, a switch back to 4-3-3 is also on the cards, with Klopp known for preferring a solid workman-like midfield against bigger opponents - although that has changed of late.
The boss could also then turn to Milner as the third midfielder, with the tried and tested trio featuring in several big games last season.
It's tricky to tell how the Reds may line up, with anything but a loss deemed to be a positive result in a game of such magnitude.
Meanwhile, Manchester City will hand a late fitness test to Kevin De Bruyne, with the midfielder missing their 3-1 win at Southampton with muscle soreness.
The Belgian is expected to play a part, with Guardiola saying: “He trained today. But tomorrow we need another check in the morning, but he is much better.”
Ilkay Gundogan is also set for a return after being sidelined with a knock, whilst Fabian Delph (suspension) and Benjamin Mendy (knee) are ruled out.
Liverpool: Alisson, Alexander-Arnold, Lovren, Van Dijk, Robertson, Wijnaldum, Henderson, Milner, Mane, Salah, Firmino.
Manchester City: Ederson, Danilo, Kompany, Laporte, Zinchenko, De Bruyne, Fernandinho, Silva, Sane, Aguero, Sterling.