Having struck late via Daniel Sturridge to earn a 1-1 draw against Chelsea on Saturday, attention returns to the Reds' European campaign.
The manager will be hoping his side can cement their place at the top of the table following their dramatic 3-2 win over Paris Saint-Germain on opening day.
The fixture at the Stadio San Paolo proves to be an intriguing one, with Napoli manager Carlo Ancelotti holding a solid record against the Reds - drawing one and winning three in 4 previous games.
The Liverpool squad will travel to Naples on Tuesday afternoon, before Klopp and midfielder Gini Wijnaldum preview the fixture at the pre-match press conference. A training session at the stadium will follow later in the evening.
Curtis Jones and Rafa Camacho - both of whom have been involved in first-team training of late, miss out on the senior squad but should play for the U19s in the UEFA Youth League.
Klopp could choose to make changes to his side from the draw at Chelsea, with the crucial Premier League fixture against Man City to come on Sunday.
Daniel Sturridge will be hoping to continue his resurgence at the club, whilst Xherdan Shaqiri and Fabinho will look to make their first European starts for the Reds.
However, it is more likely that the manager chooses to field a strong eleven in Naples as Liverpool look for their first win in two games.
Liverpool's 23-man squad
Goalkeepers: Alisson Becker, Simon Mignolet, Kamil Grabara