The Reds skipper has been involved less than he would have liked this season, having returned late to Melwood after World Cup duty and suffering a string of injuries.
The 28-year-old has most recently missed games due to a hamstring injury, making a late appearance against Fulham before the international break.
He was brought on as a substitute in England's friendly against USA, but went on to miss the Three Lions' Nations League fixture against Croatia due to another hamstring issue.
However, the Echo report that he was excluded merely as a precaution and is likely to return to action this weekend.
Henderson, who was Klopp's first choice in the deepest lying midfield role last season, will be hoping he can reclaim his spot in the starting eleven.
Naby Keita is also back to fitness after overcoming a hamstring injury of his own, having gained vital minutes for Guinea on international duty.
For the first time this season, Klopp should have all his players at his disposal, with the exception of long-term injury absentee Alex Oxlade-Chamberlain.