The Serie A side are at the top of Group C heading in to the crucial fixture, one point ahead of Paris Saint-Germain, needing just a point to secure progression.
Liverpool know they need to secure a victory to be in with a chance of qualification. Winning and keeping a cleansheet will see Jurgen Klopp's side progress, whilst conceding but winning by two goals or more will also do the job for the Reds.
Napoli head in to the game with their confidence high, sitting in second place in the league and coming off a 4-0 victory over Frosinone on Saturday.
And Ancelotti insists that he has no intention to set his side up to just defend over the course of 90 minutes.
“It's going to be a tough, exciting match. We'll go there and play our usual game. It would be counter productive to try and park the bus. Besides anything else, that's not how we play.
“We'll try to boss the game and I'm sure the lads are ready and fired up to give their absolute all.
“We'll go there with an attacking mindset.”
Napoli fielded a much-changed eleven for their victory on the weekend and Ancelotti hopes that his side will be well rested to be ready for what Anfield has to offer.
“I rotated the squad not just to rest a few legs but also to give playing time to some of the other lads. I need everyone and this is the way forward,” Ancelotti added.
“The lads who came into the team performed well. They all did good things. This game was a potential banana skin and we cleared it well.”