With just another five games left of an incredible season, the Reds make the trip to the south coast to face Graham Potter's side on Wednesday night.
Liverpool are gunning for the record Premier League points tally to cap off their heroics this year, with 11 points needed from a possible 15 to equal the current record.
Klopp insisted his side "need to be ready" for the challenge Brighton pose, while he admitted the Reds need to be "patient" but "lively" to get a result.
"He is doing a really good job there, my colleague. But now since the lockdown they changed their approach a bit, they went a bit more for results," Klopp said.
"You could see that against Norwich, maybe it's not the perfect example, but I think Norwich had more possession in that game. We don't know exactly what we will face.
"A team in a good run and pretty much full of confidence about the results they had since the lockdown. We need to be ready for that.
"After that, Burnley – always difficult. After that, Arsenal fighting for Europe for sure and after that, Chelsea fighting for Champions League. Then lastly, Newcastle – probably fighting for nothing anymore but still the last home game.
"But all different and a lot of things we need always. One of these things we need is being patient but it's not something I ask for before the game because we will find out how patient we need to be.
"First and foremost, I want us to be lively, I want us to be active, I want us to be creative and I want us to be really solid, especially in protecting the counter-attacks.
"Whatever setup Brighton will choose and they used to change a lot for the specific opponent system-wise. So against us when we played here, it was kind of a 4-3-2-1, maybe they play that again.
"But we have only two days' time, so we cannot prepare for all the different systems. Most of the things the boys have to learn on the pitch and then use our principles, our patterns. Hopefully, it will work out."
Watch Klopp's press conference in full above.