The Reds return to Premier League action following a two-week international break that gave some of the Reds' injured stars added rest ahead of an upcoming busy spell in the season.
Liverpool goalkeeper Alisson has been sidelined since the first Premier League fixture of the season against Norwich at Anfield, however, he is back in contention for the trip to Old Trafford after returning to full-team training on Tuesday.
Mohamed Salah also took part in training at Melwood, despite initial suggestions that the Egyptian would struggle to shrug off a knock sustained against Leicester ahead of the international break.
In addition to the duo, Klopp also welcomed back Joel Matip, who has missed the last two games due to injury, with Dejan Lovren and Joe Gomez filling in for the Cameroonian. Alex Oxlade-Chamberlain is also in contention after missing the win over Brendan Rodgers' side.
Oxlade-Chamberlain is unlikely to take up a starting role against Ole Gunnar Solskjaer's side, with Klopp likely to stick to a midfield three of Fabinho, Jordan Henderson and Gini Wijnaldum, as he has done regularly this term.
Liverpool's front-three of Mohamed Salah, Roberto Firmino and Sadio Mane is set in stone, with only questions left about the Reds backline, with Alisson and Matip both vying to come back into the starting eleven.
Adrian has performed admirably in place of Alisson so far this season. However, the Brazilian is a key component of Liverpool's defence stability and it is hard to imagine Klopp leaving him on the substitutes bench, if he is fully fit.
Matip is equally likely to come straight back into the side, with neither Gomez nor Lovren hugely convincing during the Reds' wins over Salzburg and Leicester.
United boss Solskjaer described this weekend's clash as the "perfect game" despite his side's poor form at the start of the current campaign as he hopes his side respond against their old rivals.
Meanwhile, the home side have won just once in their last five Premier League games, having lost 1-0 to Newcastle in their last outing. They sit in 12th position in the league table, with little sign of optimism amongst supporters.
They are set to welcome back several of their starters after the international break, with Anthony Martial, Aaron Wan Bissaka, Luke Shaw and Victor Lindelof all hoping to be back in contention for the visit of the Reds.
However, they will be without goalkeeper David de Gea, who suffered an innocuous knock during Spain's Euro 2020 qualifier in Sweden on Tuesday night.
"David needs a scan," Solskjaer told Sky Sports. "I think he'll be out. It certainly looked like it anyway judging on last night so it's just one of those things.
Paul Pogba will be another huge absentee for United after being confirmed sidelined with an ongoing ankle injury.
Both managers will provide a full injury update in their respective press conferences later this week.