Klopp is yet to win a game at Old Trafford as Liverpool manager, however his Reds side go into the fixture on the back of a seven-match unbeaten run, including five clean sheets.
“It’s the biggest game I can imagine, I’m really looking forward to it,” Klopp told reporters at Melwood on Friday.
“These games are difficult, though. We need to be at 100 per cent, if not a bit more.
“It’s a good moment to go there but they have outstanding quality, and they are at home, which we would say is an advantage if we were at Anfield.
“They are a very experienced team with a very experienced manager. It’s quite a job we have to do.
“I have no problem with defending. People say we play a specific style, they (United) play a specific style. Everybody makes a big thing of it. It’s about winning and there are different ways to win football games.
“We have to defend there with all we have, and not gamble and think we are flying. They are too strong physically and technically (to take for granted).
“It is not a battle of systems or philosophies. I hope when United attack, all my players are involved in defending.
“But over 90 minutes, we want to bring our football on the pitch.
“Counter-pressing against a team like United is unbelievably important. There’s a reason why they have two points more than us.
“If we win we have one point more but that’s not big for the rest of the season.
“The only thing we can positively influence is winning the next match and that’s United. I don’t need to talk about the table.”
Watch the full press conference above.