The 21-year-old suffered a fracture to his left leg in Wednesday's victory against Burnley at Turf Moor, with the club confirming he was sidelined for six weeks.
Gomez will be a huge loss to Liverpool, having formed a formidable partnership with Virgil van Dijk at the centre of defence that has seen Liverpool concede just six goals in the league all season.
The England international could miss up to nine games for the Reds: Bournemouth (A), Napoli (H), Man United (H), Wolves (A), Newcastle (H), Arsenal (H), Man City (A), Wolves (A [FA Cup]) and Brighton (A).
However, speaking at his pre-match press conference, Klopp insisted that he can mitigate Gomez's loss and he has "a lot of players who can play that position."
“It’s just a shame for the boy,” Klopp said of Gomez’s injury.
“For us he was in outstanding shape and he helped us a lot, especially because we could make these changes with Trent and Joe.
“That was really important because Trent is still a young boy and we cannot push him through 20 games in a row.
“He would probably say he is OK but I think it is responsible we have an eye on that.
“I have a plan – surprisingly. We will see what we will do but we have other options of course.
“There are a lot of players who can play that position, especially in the way we play now.
“Wait a little bit and you will see which other options we have.”