The Reds will be looking to continue their relentless march at the top of the Premier League table with a win against Ole Gunnar Solskjaer's floundering Man United side.
While Liverpool have stormed ahead this season, Man United have struggled with staying consistent. Promising results have often been followed by lethargic and uninspiring performances.
However, form matters rarely in games such as these, with Klopp highlighting the magnitude of the fixture: “It’s a very, very important football game. Very important.
“We all know about the importance [of the game] to our supporters, but we play all games for our supporters. Not only these games.
“Liverpool is the natural enemy of some clubs. We have more natural enemies than other clubs have and the reason is our history.
"But we have to write our own history and that means we have to play games in our own way.”
Liverpool's only blemish to their league record this season is a 1-1 draw away to Solskjaer's side earlier this term. Adam Lallana struck late to save a point for the Reds, who dominated large periods of the game.
Klopp insists his side must make take advantage of having the majority of the ball, with the manager expecting United to once again line up fairly defensively.
“We have to learn to deal with games like this in the right manner. We did not too bad in the past but we still can improve,” Klopp said.
“The game at United is a good example; we were not at our best in a game where we should be, because of the quality of the opponent.
“We were not bad that day but we were not at our best, and we have to make it more likely that we are at our best.
“The games were not games you would imagine for United against Liverpool. In the past, there were good times for Manchester United and good times for Liverpool, there was usually one clear favourite but both teams tried to win it.
“In the last years, the away games especially were strange from that point of view.
“It is strange when you play against a high, high-quality team—which United still is—and they play the way they play. That makes life really difficult.
“We had the same with Tottenham, after 70 minutes we had roundabout 70 percent possession. That’s not normal, how can you expect something like that?”
“Joel and Fabinho trained completely normal yesterday and the day before so that means they are likely to be in the squad,” Klopp told reporters.
“The other three not (Lovren, Milner, Keita), but they are getting closer and closer – Dejan I think will train 100 percent from Monday on and the other two I don’t know exactly.
“I cannot rush it so when someone tells me they are ready I take them back in training.”