Jurgen Klopp's side are back at the Puskas Arena as they look to progress to the last eight following a 2-0 win in the first leg against Julian Nagelsmann's side.
Despite no sign of things improving in the Premier League, the hope is the change in the competition can give the Reds a much-needed impetus as they enter the final months of a troublesome season.
We'll have all the latest throughout the day, including confirmed team news, live social media updates and post-match reaction.
Liverpool: Alisson, Alexander-Arnold, Phillips, Kabak, Robertson, Fabinho, Wijnaldum, Thiago, Mane, Salah, Jota.
Substitutes: Adrian, H. Davies, Milner, Keita, Oxlade-Chamberlain, Jones, Tsimikas, Shaqiri, Origi, B. Davies, R. Williams, N. Williams.
RB Leipzig: Gulacsi, Mukiele, Upamecano, Klostermann, Kampl, Sabitzer, Adams, Olmo, Nkunku, Forsberg, Poulsen.
Substitutes: Martinez, Konate, Orban, Haidara, Hwang, Sorloth, Samardzic, Kluivert, Halstenberg, Henrichs.
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