Man City's quality shone through despite a promising start from Liverpool as Pep Guardiola's side ruthlessly punished some uncharacteristic lapses in concentration.
The Reds boss is keen for his side to show a response against Aston Villa at Anfield, but maintains there's no need to “change everything.”
“We didn't lose a lot of games in the last two-and-a-half years or so, but we lost them, and they always feel really like defeats,” Klopp told reporters.
“So far we always used that for the next games – not only the next game but for the next games, yes.
“If you think about things we didn't do well, so in this department, we have to show a reaction. But the reaction doesn't mean we have to change everything. We just have to be spot on in these moments, and we cannot switch off or whatever.
“As an example, Joe was alone in the challenge with Sterling, but he should have shouted at everybody around because he knew that he was alone, the others maybe didn't at that moment. These are the situations we have to change.
“Hendo could have been there. Usually, Fabinho should have been there, but he pushed up and all that stuff. So there's obviously an explanation.
“Yes, we have to be at 100 per cent, and we knew that always, we knew it always from day one. If you want to reach something special, the only way to do that is being 100 per cent in the specific game, which means in all specific situations.
“Do we have to lose 4-0 to learn that? I am not sure, but it can help. It makes the point absolutely clear. We will try again to use the information from last night.”
When asked whether he would mention the City defeat in his pre-Villa team talk, Klopp replied: “I don't use that, I never used things like this in pre-match meetings, I use them in post-match meetings.
“It means after the game we speak about what was right and wrong, but in the pre-match meeting we prepare for the next game.
“There is no time for worrying about things we did not right in the last game; it's not like constantly saying, ‘Here we did that… we had that problem and that problem… if we have that today again…' and stuff like this.
“So, in the post-match meeting we make a resumé of the last game pretty much and if there are positives, I mention them because I am not from a newspaper or something like that, I don't have to put the finger in only one direction and make a headline. I have to write the full article if you want and that's what I try to do.
“If there are positives, I mention them. If there are negatives, I mention them if I think it is necessary. If I know they know already, if it was so obvious, then maybe I don't mention them.
“The pre-match meeting is about the next game and it's about what we have to do in this game. We would have had to do that if we had won the last game as well, so there is no difference, it is just about preparing this game with the special needs of the game and the opponent, nothing else.”
Klopp also provided an update on the fitness of his squad, revealing Xherdan Shaqiri could be in contention after returning to training this week.