It's Liverpool's second outing in Europe this season as they look to build on their opening 3-2 victory over Milan at Anfield just under a fortnight ago.
Jurgen Klopp's side head into their group B fixture with familiar foes Porto following a disappointing result at the weekend, having given up a lead twice after coming from behind to draw 3-3 with Brentford.
Meanwhile, the hosts have won their last two Primeira Liga fixtures after earning a point against Atletico Madrid on the opening day of their European campaign.
It should be an entertaining 90 minutes at the Estadio so Dragao if recent meetings between the sides are anything to go by. The Reds have run out 4-1 and 5-0 winners at the stadium within the last three years.
The hope is the Reds can solidify their position at the top of group B with a victory, which would also extend their unbeaten run in all competitions to 18 games.
In addition to Alexander-Arnold and long-term absentee Harvey Elliott, Liverpool will also continue to be without the services of Thiago, who is set to be out of action until after the October international break.
Updated: 18:45 (BST)
Porto: Diogo Costa, Corona, Pepe, Marcano, Zaidu, Sergio Oliveira, Uribe, Otavio, Luis Diaz, Taremi, Toni Martinez. Substitutes: Marchesin, Fabio Cardoso, Francisco Conceicao, Pepe, Grujic, Manafa, Vitinha, Wendell, Joao Mario, Bruno Costa, Evanilson e Fabio Vieira.
Liverpool: Alisson, Milner, Matip, Van Dijk, Robertson, Fabinho, Jones, Henderson, Mane, Salah, Jota. Substitutes: Adrian, Kelleher, Konate, Keita, Firmino, Gomez, Oxlade-Chamberlain, Minamino, Tsimikas, Origi, Williams, Phillips.
UK and USA TV Streaming
Porto vs Liverpool is available to stream in the United Kingdom on BT Sport 3, which is available on Sky channel 417 and Virgin Media channel 529.
Supporters in the United States can watch live on Paramount+ at 15:00 (ET).
Worldwide TV Streams
For viewers across the world, please refer to the list below for channels showing the game worldwide.
beIN SPORTS CONNECT, TV3+ (HD), Flow Sports App, Digiturk Play, Cytavision Sports 1, Sky Sport 3 HD Italia, Viaplay Finland, Movistar+, SuperSport 3 Africa, Setanta Sports Kazakhstan, beIN Sports Connect Thailand, SuperSport 3 Nigeria, QQ Sports Live, Canal+ Sport 2 Poland, Watch ESPN Brasil, SPS HD, Sport TV3,BT Sport, Canal+ Sport 2 Afrique, Stod 2 Sport, TV2 Sport Premium, Now 621, TSN GO, beIN Sports 1 HD, Citi FM, LeTV Sports Hong Kong, Sky Sports, Match TV Football 1, Viasat Football HD, Cosmote Sport 1 HD, Canal+ Sport Online, Diema Sport 2,PPTV Sport China, TSN5, Sportklub 2 Slovenia, TSN4, beIN Sports HD 2,620 PLTV, NTV+ Sport Online, Canal+ NOW, beIN Sports 1 Indonesia, Star Sports Select 2, Viasat Ultra HD, SKY Go Italia, Star Sports Select HD2, SKY Planeta Futbol, Optus Sport, Spiler TV, Ssports Live, BesTV, SFR Sport 1, Movistar TV Futbol, Sport 3, Digi Sport 1, Viaplay Denmark, ESPN Brasil, Play Sports 1, OLL.tv, Futbol 1, Ziggo Sport Select, SportsNavi Live, CBS,SuperSport 1 Digitalb, DAZN Europe, Hotstar, Ziggo Sport 14