Whilst the season has only just begun, both sides will be intent on maintaining their flawless start to the campaign with the likes of fellow title rivals Manchester City and Manchester United having both already dropped points.
Thomas Tuchel's side inflicted Liverpool's fifth consecutive home defeat when the two sides met back in March. Whilst the visitors should be in high spirits, having further improved since, the Reds are no longer in the midst of an injury crisis that saw Fabinho and Ozan Kabak paired at the back during the previous encounter.
It's the Reds' first real test of the season and the hope is that with supporters back in the stadium and a near-empty treatment room, Liverpool can continue to build momentum with three points against the Blues.
Klopp confirmed James Milner is expected to miss out, but besides the vice-captain, the Liverpool boss has little else to worry about when it comes to injuries.
Andy Robertson trained as usual during the week and could replace Kostas Tsimikas at left-back, whilst there could also be a return for Fabinho, who missed the clash against Burnley owing to compassionate reasons following the death of his father.
Harvey Elliott could drop down to the bench to facilitate a first start of the season for Thiago, who came off the bench last week. Roberto Firmino could also be given the nod up front in place of Diogo Jota.
Updated: 16:30 (BST)
Liverpool: Alisson, Alexander-Arnold, Matip, Van Dijk, Robertson, Fabinho, Henderson, Elliott, Firmino, Mane. Substitutes: Kelleher, Konate, Thiago, Keita, Gomez, Minamino, Oxlade-Chamberlain, Jota, Tsimikas.
Chelsea: Mendy, Azpilicueta, Christensen, Rüdiger, James, Jorginho, Kante, Alonso, Mount, Havertz, Lukaku. Substitutes: Arrizabalaga, Kovacic, Werner, Loftus-Cheek, Chalobah, Silva, Ziyech, Chilwell, Hudson-Odoi.
UK and USA TV Streaming
Liverpool vs Chelsea is available to stream in the United Kingdom on Sky Sports, which is available on Sky channel 401 and Virgin Media channel 501.
Supporters in the United States can watch live on NBCSN at 12:30 (ET).
Worldwide TV Streams
For viewers across the world, please refer to the list below for channels showing the game worldwide.
S Sport, Eurosport Player Denmark, TV2 Sumo, SuperSport Maximo, Idman TV, Viasat Ultra HD, 101 Soccer Streams, RMC Sport en direct, 102 (HD) mio Stadium, beIN Sports 1 Thailand, Liveonscore, TSN4, Skynet Sports 6, Cytavision Sports HD, Flow Sports App, Sky HD, SBS Live, RMC Sport 1, GO TV Anywhere, ESPN Brasil, Stod 2 Sport, Viaplay Finland, Match TV Football 1, Flow Sports 1, Star Sports Select HD1, ESPN2 Andina, ESPN Play Sur, SL2G, #Vamos, PPTV Sport China, FootyBite, Bongda TV, Hotstar, beIN Sports HD 11, Sky Sport Football, DIGI GO, Sportklub 1 Croatia, SBS, beIN Sports Connect New Zealand, Ziggo Sport Select, Now Player, Play Sports 1, Viasat Sports Premium, Sky Sports Premier League Ireland, SportKlub 1 Slovenia, RDS GO, TSN2 Malta, Guangdong Sports Channel, Sky Pacific, DAZN, Digiturk Play, SportsNavi Live, Astro Go, Givemereddit Streams, Star Sports Hindi 1, Sport TV2, Sky Sport Uno, S Sport+, Setanta Sports Kazakhstan, SKY Go Italia, 620 Now Premier League TV, Spiler1, Optus Sport, SuperSport 3 Africa, Now E, Cytavision Sports 3, Watch ESPN Brasil, Canal+ Sport 2 Afrique, Kwese Live, OLL.tv, QQ Sports Live, Astro Supersport, RDS 2, Kwese Free Sports, SuperSport 3 Nigeria, Viaplay Sweden,TSN GO, NTV+ Sport Online, Viasat Football HD, Viaplay Denmark, SCTV 17,beIN SPORTS CONNECT, Trees Network, ESPN2 Sur, Ziggo Sport 14, 621 Now Premier League 1, SportKlub 1 Serbia, beIN Sports 1 Indonesia, TV2 Sport Premium, TV3+ HD, Futbol 2, Diema Sport 2, beIN Sports Connect Indonesia, TVPlay Sports, Eurosport Romania, SPOTV ON, Blue To Go Video Everywhere, Ssports Live, BesTV, Digi Sport 4.