Virgil van Dijk and Trent Alexander-Arnold replaced Joel Matip and Joe Gomez (injured) in the starting eleven for Jurgen Klopp's side who, after the 4-1 thrashing at Wembley earlier in the season, were in search of revenge.
The Reds got the perfect start when Mohamed Salah scored his 20th league goal of the season
(in 25 games) inside three minutes.
The Egyptian winger capitalised when the ball broke for him on the edge of the box and calmly rolled the ball past Hugo Lloris in front of the Kop.
Alexander-Arnold was a regular down the right hand side, creating chances from balls into the box. First James Milner‘s shot looped wide via a deflection, then Roberto Firmino‘s glanced header from Alexander-Arnold's excellent cross from the right went just wide.
Loris Karius made a good save to deny Moussa Dembele as the first half ended 1-0 to the Reds. Jurgen Klopp's side were marginally the better team in the 45 minutes.
In the second half, Loris Karius denied Son Heung-Min as Spurs began to dominate the ball and the home side. Jurgen Klopp's men struggled for possession and a double sub just after the hour saw Gini Wijnaldum and Alex Oxlade-Chamberlain replace Jordan Henderson and Sadio Mane.
That change did little to stem the flow of the game, with Spurs continuing to dominate but failing to break down a stubborn Liverpool centre consisting of Lovren and Van Dijk.
Klopp introduced Joel Matip and changed to a back five in an attempt to see out the win, but the visitors finally got their break through with 10 minutes to go. Spurs' sub Victor Wanyama hammered home from 25 yards seconds after coming on.
Things appeared to get worse for Liverpool when Karius was judged to have taken out Harry Kane for a penalty with five minutes to go. Replays showed their was minimal contact between the two as arguments continued on the pitch. The German then went on to make a save to deny Kane from the spot.
Liverpool were playing like a team with a man sent off, however Mohamed Salah came forward to score a sensational goal in injury time, beating four defenders and finishing past Lloris for an incredible solo goal. Anfield, and Klopp, went crazy as the Egyptian looked to secure a 2-1 win for the Reds.
However the action wasn't over with a bizarre penalty being awarded for a foul by Van Dijk on Dembele – with the linesman awarding the spot kick after the referee had waved play on. Kane dispatched the penalty this time with the final kick of the game. The game ended 2-2 in an ultimately frustrating night for Jurgen Klopp's side.
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