Liverpool start both Mohamed Salah and Wataru Endō in what is their last games for Liverpool before heading off to the Africa Cup of Nations and the Asian Cup this month.
Ibrahima Konaté returns to the starting line-up to partner Virgil van Dijk after he was rested against Burnley with 20-year-old Jarell Quansah taking his place in the side.
It's a welcome return to the Liverpool squad for Alexis Mac Allister who has missed the last six games in all competitions due to a knee injury.
Liverpool Lineup
Alisson, Alexander-Arnold, Konaté, Van Dijk, Gomez, Endo, Szoboszlai, Jones, Salah, Núñez, Díaz
Substitutes
Kelleher, Gakpo, Mac Allister, Elliott, Jota, Gravenberch, McConnell, Quansah, Bradley
Newcastle Lineup
Dubravka, Livramento, Schär, Botman, Burn, Miley, Guimarães, Longstaff, Joelinton, Isak, Gordon
Substitutes
Karius, Gillespie, Dummett, Lascelles, Ritchie, Krafth, Hall, Almirón, A. Murphy
LFC Globe Verdict
It's a busy 10 days for Liverpool who compete in both the FA Cup and EFL Cup in the first week of January.
Despite a lengthy injury list, the squad depth is at an all-time high which allows Jürgen Klopp to field an extremely strong line-up despite missing the likes of Andy Robertson, Thiago Alcântara, and Kostas Tsimikas.
Darwin Nùñez's goal against Burnley will certainly fill the Uruguyuan with confidence as he'll score against the team he netted a brace in earlier this season in a 2-0 win for Liverpool.