It's that time again as the two most decorated clubs in English football face each other with Jurgen Klopp's side making the trip up the M62 to face familiar rivals Manchester United.
It's a run that also sees that them unbeaten in their last 18 Premier League games, which includes a 4-2 win at Old Trafford in the corresponding fixture last season.
The hosts meanwhile have struggled to remain consistent under manager Ole Gunnar Solskjaer, with midweek's turnaround against Atalanta doing little to stem the unease within Stratford End faithful.
With fellow title rivals gaining wins this weekend, it's a highly anticipated meeting between the two sides and the hope is the Reds can return to Merseyside with all three points in the bag.
The Reds boss will be able to call upon Curtis Jones after the youngster missed the Reds' last two outings with a knock, whilst Fabinho is likely to be included from the off after coming on from the bench in midweek.
Thiago remains sidelined as the Reds' only other injury concern alongside long-term absentee Harvey Elliott.
Manchester United, meanwhile, could be without summer signing Raphael Varane, whilst there are also doubts over the fitness of trio Fred, Bruno Fernandes and Marcus Rashford.
Updated: 15:30 (BST)
Man United: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, McTominay, Fred, Greenwood, Fernandes, Rashford, Ronaldo. Substitutes: Henderson, Bailly, Dalot, Matic, Pogba, Lingard, van de Beek, Sancho, Cavani.
Liverpool: Alisson, Alexander-Arnold, Konate, Van Dijk, Robertson, Henderson, Milner, Keita, Jota, Salah, Firmino. Substitutes: Adrian, Mane, Gomez, Oxlade-Chamberlain, Jones, Minamino, Tsimikas, Origi, Matip.
UK and USA TV Streaming
Man United vs Liverpool is available to stream in the United Kingdom on Sky Sports, which is available on Sky channel 401 and Virgin Media channel 501.
Supporters in the United States can watch live on NBCSN at 11:30 (ET).
Worldwide TV Streams
For viewers across the world, please refer to the list below for channels showing the game worldwide.
TeleClub Sport Live, beIN Sports Connect Australia, Viaplay Sweden, Arena Sport BIH, Viaplay Norway, Astro Supersport, Cosmote Sport 1 HD, Futbol 2, TV3 Sport, Viaplay Finland, CCTV 5+ VIP, SportKlub 1 Slovenia, Armenia TV, Telekom TV Live, Fox Sports Cono Sur, Ring.bg, beIN Sports Arabia 17 HD, SuperSport Maximo, Sky Go Deutschland, SKY PerfecTV LIVE, Tivibu Spor 3, Sport TV1, BT Sport 3 (Republic of Ireland), Esporte Interativo 2, beIN Sports 2, Proximus 11+, TSN2, Sport 1 Hungary,Viasat Ultra HD, beIN Sports Spain, Sky Sport 3/HD, Viaplay Denmark, beIN SPORTS 3 Australia, Voyo Sport, beIN Sports Connect Indonesia, SONY TEN 1, Arena Sport 1, Fox Sports Chile, Viasat Sport, TV6 Sweden, Match TV Football 1, Sukachan 1, Canal+ Sport 2 Afrique, SBS Live, Cytavision Live, Arena Sport 1 Serbia, Viasat Ultra HD, Fox Sports Cono Norte, Cytavision Sports 2, Sky Sport 3 NZ, PPTV Sport China, SBS,Sky Sport 1 Switzerland, NTV+ Sport Online, beIN Sports 2 Indonesia, Eir Sport 2, Astro Go, Stod 2 Sport, TSN GO, Klik SPORT, Sky Sport 1 HD, Go Sports 2, Canal+ Sport Online