It doesn't come much bigger than this at such an early stage in the season as Liverpool collide with Pep Guardiola's side at Anfield.
The Reds are the only unbeaten side in the Premier League this season and they should be in a confident mood heading into the fixture following midweek's drubbing of Porto.
The Reds tasted a 4-1 defeat in the same fixture last season, during their especially barren run at Anfield at the start of 2021. However, much has changed since that evening, which saw Fabinho and Jordan Henderson line up in the heart of the defence in front of an empty Anfield.
The victors of the clash will head into the October international break sitting at the top of the Premier League table after eight games and the hope is the Reds, helped by a raucous Anfield atmosphere, can do the business and secure an early advantage against a fellow title rival.
Liverpool will remain without the services of Trent Alexander-Arnold, who missed midweek's win over Porto with a groin injury sustained during training. The Reds right-back joins Thiago and Harvey Elliott on the sidelines.
Curtis Jones is likely to start in midfield following his influential role in midweek, whilst both Diogo Jota and Roberto Firmino will be hopeful of a starting berth alongside Sadio Mane and Mohamed Salah up front.
Updated: 15:30 (BST)
Liverpool: Alisson, Milner, Matip, Van Dijk, Robertson, Fabinho, Henderson, Jones, Salah, Jota, Mane. Substitutes: Kelleher, Konate, Keita, Firmino, Gomez, Oxlade-Chamberlain, Minamino, Tsimikas, Williams.
Man City: Ederson, Walker, Dias, Laporte, Cancelo, Rodrigo, De Bruyne, Bernardo, Jesus, Foden, Grealish. Substitutes: Steffen, Carson, Stones, Ake, Sterling, Torres, Fernandinho, Mahrez, Palmer.
UK and USA TV Streaming
Liverpool vs Man City is available to stream in the United Kingdom on Sky Sports, which is available on Sky channel 401 and Virgin Media channel 501.
Supporters in the United States can watch live on NBCSN at 11:30 (ET).
Worldwide TV Streams
For viewers across the world, please refer to the list below for channels showing the game worldwide.
Flow Sports App, TSN GO, Sky Sport 1 HD, Sky Sport 1 Switzerland, nc+ GO, beIN Sports Connect Australia, ESPN Brasil, TSN2, DAZN Europe, PremiumSport 2 HD, PPTV Sport China, RTP 1, Now 621, TSN5, Watch ESPN Brasil, Movistar+, SuperSport Maximo, Viaplay Sweden, Sky Sport 3 HD Italia, TSN3, Viasat Sport Baltic, Sport 1 Hungary, NBCSN, Viaplay Finland, Arena Sport 1, Ssports Live, Sky Go Deutschland, CCTV 5+ VIP, Astro Supersport, Cytavision Sports 2, J Sports 2, SBS, SKY PerfecTV LIVE, Voyo Sport, QQ Sports Live, Canal+ NOW, LeTV Sports Hong Kong, SuperSport 3 Nigeria, Digi Sport 5, SuperSport 6 Africa, Cytavision Live, SBS Live, Ring.bg, TV6 Sweden, Canal+ Sport Online, Sukachan 1, nSport+, TDM HD, Super Soccer TV, Viasat Football HD, Idman TV, Viaplay Denmark, beIN Sports Connect Indonesia, Astro Go, SuperSport 3, Esporte Interativo 2, Ziggo Sport Select, beIN Sports 1 Indonesia, TV3 Sport, Telekom TV Live, SONY TEN 1 HD, Digiturk Play, ESPN2 Andina, TV2 Sport Premium, Futbol 2, 6'eren, beIN Sports Spain, Sky HD, SPS HD, SBS ESPN Korea, Hotstar, Canal+ Sport, Arena Sport BIH, SuperSport 3 Africa, 02 (HD) mio Stadium, 620 PLTV, NTV+ Sport Online, beIN Sports 1, Viasat Ultra HD, Eir Sport 2, TV2 Sumo, Telekom Sport 2 Romania, Match TV Football 1, beIN Sports 2 Indonesia, beIN Sports Arabia 2 HD, SONY TEN 1, Sport TV3, Premium Play, Canal+ Sport 2 Afrique, Stod 2 Sport, beIN Sports 2, Cosmote Sport 1 HD, TNT, SportKlub 1 Slovenia, OLL.tv, Tring Sport 2, Diema Sport 2, beIN Sports Connect Espana, Sky Sport 3 NZ, Optus Sport, SFR Sport 1, beIN LaLiga