Spurs are in action against Wolverhampton Wanderers earlier in the day and could reduce the gap to just three points at the summit of the league.
Liverpool have enjoyed a 100 per cent record in December so far and victory at Anfield will be another step in the race for the title.
Jurgen Klopp is not expected to rotate too much from the 4-0 win over Newcastle on Boxing Day, with a five-day rest period ahead of the visit of Etihad on 3rd January.
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