City are in action against Crystal Palace before the Reds' game on Sunday and it is likely that the Reds will need all three points against the Blues to retain their place at the top of the table having played a game more.
However, Chelsea are in good form with four wins in their last four fixtures and Klopp highlighted what a tough test they will be for his side during his pre-match press conference at Melwood.
“Chelsea are in a really good moment, that's the most important thing for me to know,” Klopp told reporters.
“We now had two opportunities to watch them during the week, Monday against West Ham and yesterday night we watched them, of course, in Prague.
“They are in a really good moment, that's the truth, and they could make [something like] seven changes between the two games, so rested a lot of players and still won the game last night.
“They're now in a good position in the Europa League as well, so that's the case.
“Chelsea are in a good shape, Hazard in a very good shape, that's a big game for us obviously.
“Not an easy one, we know that, but come on, we're in a good shape as well, it's Anfield.
“And, I've said it a few times, we have to create the power of Anfield and use the power of Anfield again.
“I'm so happy with our crowd, with our supporters, how they dealt with everything in the last month, it's really great how we all develop together.
“And this is a good moment to show all the improvement, and put all the positive vibes and energy into this game.
“Not because it's the last ‘big' one, because we only have big games now. No, because it's the only one we play this weekend.
“It's against a very strong opponent, and we need all our resources to win it, and that's obviously the target.”