The Reds return to Premier League action after two weeks off as they face Mauricio Pochettino's side at Anfield.
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Henderson starts in his usual deep-lying midfielder role and is joined by Milner and Gini Wijnaldum, with Fabinho, Lallana and Naby Keita on the substitutes bench.
Liverpool: Alisson, Alexander-Arnold, Matip, Van Dijk, Robertson, Henderson, Wijnaldum, Milner, Mane, Salah, Firmino.
Substitutes: Mignolet, Fabinho, Lovren, Keita, Lallana, Shaqiri, Origi.
Tottenham: Lloris, Trippier, Alderweireld, Sanchez, Vertonghen, Rose, Sissoko, Eriksen, Dele, Lucas, Kane.
Substitutes: Gazzaniga, Davies, Foyth, Skipp, Wanyama, Son, Llorente.