The Reds are back in action just three days after an intense Merseyside derby that saw them earn three points with a dramatic late victory.
With such little recovery time between fixtures, Klopp was always expected to make some changes to his starting line-up.
Sadio Mane and Andy Robertson were major doubts ahead of the game, and neither are present for the Reds tonight.
Liverpool XI: Alisson, Gomez, Van Dijk, Matip, Moreno, Henderson, Milner, Keita, Shaqiri, Sturridge, Origi.
Substitutes: Mignolet, Fabinho, Firmino, Salah, Lallana, Camacho, Alexander-Arnold.
Burnley: Hart, Bardsley, Tarkowski, Mee, Taylor, Gudmundsson, Cork, Westwood, Brady, Barnes, Wood.
Substitutes: Heaton, Lowton, Vokes, Hendrick, Lennon, Vydra, Long.