Liverpool face bottom-placed Fulham for an early 12pm kick-off at Anfield, with the Reds looking to return to winning ways after defeat in midweek.
In midfield, Shaqiri gets a start as the most advanced midfielder after being left out in Belgrade.
The Swiss international is joined by Fabinho and Gini Wijnaldum in the centre of the park.
Mohamed Salah, Roberto Firmino and Sadio Mane start up front once again as they look to return to goalscoring form.
Liverpool XI: Alisson, Alexander-Arnold, Gomez, Van Dijk, Robertson, Fabinho, Wijnaldum, Shaqiri, Mane, Salah, Firmino.
Substitutes: Mignolet, Lovren, Milner, Keita, Henderson, Sturridge, Moreno.
Fulham: Rico, Christia, Odoi, Mawson, Marchand, Anguissa, Chambers, Cairney, Schurrle, Mitrovic, Sessegnon.
Substitutes: Bettinelli, Fosu-Mensah, Ream, Seri, Johansen, Kebano, Vietto.