It's a huge downturn since being top of the table at Christmas, with Sunday's opponents stealing a march ahead of them after contrasting fortunes this month.
Whilst the two sides played out a bore draw at Anfield earlier this month, the FA Cup should instigate both managers to take their foot off the pedal, with a result needed on the night - whether in 90 minutes, extra-time or penalties.
The champions are in dire need of a confidence boost given their recent run, with the Reds netting just once in their last five league games, which have resulted in two defeats and three draws.
The hope is Liverpool can finally click back into gear and find their shooting boots to knock their fierce rivals out of the competition. It's set to be an exciting 90 minutes of football in Manchester...
Skipper Jordan Henderson is likely to be missing again after missing the defeat to Burnley with a minor injury, whilst Joel Matip - who returned on Thursday - could be rested again as Klopp looks to keep him fit.
Updated: 4pm (GMT)
Liverpool: . Substitutes: .
Man United: . Substitutes: .
UK and USA TV Streaming
Man United vs Liverpool is available to stream in the United Kingdom on BBC One, which is available on Sky and Virgin Media channel number 1.
Supporters in the United States can watch live on ESPN+ at 12pm (ET).
Worldwide TV Streaming
For viewers across the world, please refer to the list below for channels showing the game worldwide.
621 Now1, True Premier Football HD 1, Sport TV1, Now Player, SPS HD, Sky HD, Sportklub 1 Croatia, True Premier Football HD 2, Now E, GO TV Anywhere, Astro Go, Eleven Sports 1 Taiwan, Sky Sports Premier League Ireland, TVPlay Sports, SportKlub 1 Slovenia, DAZN, TVPlay SportsX, S Sport+, Sky Sport 1 HD, Setanta Sports Ukraine, SiminnSport, beIN SPORTS CONNECT, ESPN2 Sur, Belarus 5, beIN Sports HD 2, Viaplay Finland, Sky Go, RMC Sport en direct, Xee, QQ Sports Live, TSN2 Malta, Spark Sport, RMC Sport 1, Viaplay Sweden, Viasat Football HD, SportKlub 1 Serbia, Play Sports 2, Idman TV, SuperSport 3 Africa, SuperSport Maximo, Viasat Sports Premium, Sky Sport Football, Eleven Sports Plus, PPTV Sport China, TV2 Sumo, Sport TV LIVE, Mola TV, Optus Sport, NOW TV, DAZN Spain, ESPN Play Sur, SKY Go Italia, Viaplay Denmark, Truevisions Anywhere, Premier Sport, Canal+ France, DIGI GO, Cosmote Sport 1 HD, VOOsport World 1, ESPN Brasil.