All focus now turns to Ralph Hasenhuttl's side, who visit Anfield on the back of a surprise defeat at Carrow Road last weekend after going unbeaten in their previous four league games.
Liverpool meanwhile should be full of confidence having scored in 22 Premier League games in a row since March and also scoring 2 goals or more in their last 16 consecutive fixtures in all competitions.
It should be another exciting 90 minutes of football on a chilly afternoon at Anfield, with the Reds looking to seal all three points and move up to just a point below league leaders Chelsea, even if for only 24 hours.
Liverpool had no fresh injury concerns to report following midweek's win over Porto that saw the boss rotate some of his key stars and provide minutes to those in the wider squad.
Andy Robertson, James Milner and Divock Origi returned to action following injuries and the trio should be involved in the squad once again. However, the Reds remain without Joe Gomez, Curtis Jones, Naby Keita and Roberto Firmino, as well as long-term absentee Harvey Elliott.
Trent Alexander-Arnold, Virgil van Dijk, Fabinho and Diogo Jota are all expected to return to the starting eleven after not featuring from the off against Porto, whilst Robertson will be vying for a starting berth in front of Kostas Tsimikas.
Updated: 14:00 (BST)
Liverpool: Alisson, Alexander-Arnold, Konate, Van Dijk, Robertson, Fabinho, Henderson, Thiago, Salah, Jota, Mane. Substitutes: Kelleher, Milner, Oxlade-Chamberlain, Minamino, Tsimikas, Origi, Matip, Williams, Morton.
Southampton: McCarthy, Lyanco, Romeu, Ward-Prowse, Armstrong, Adams, Perraud, Broja, Livramento, Salisu, Bednarek. Substitutes: Forster, Walker-Peters, Long, Redmond, Smallbone, Tella, Diallo, Walcott, Valery..
UK and USA TV Streaming
Due to the 3pm blackout rule, Liverpool vs Southampton is not televised live in the United Kingdom.
Supporters in the United States can watch live on USA Network at 10:00 (ET).
Worldwide TV Streams
For viewers across the world, please refer to the list below for channels showing the game worldwide.
Fox Sports Chile, beIN Sports Arabia 12 HD, Sport TV1, Fox Sports Cono Sur, beIN Sports 2, Arena Sport BIH, Arena Sport 1, beIN Sports Spain, SuperSport 6 Africa, Premium Play, Viasat Sport, Arena Sport 1 Serbia, Stod 2 Sport, Viaplay Finland, Sport 1 Hungary, Telekom Sport 2 Romania, Canal+ NOW, Sukachan 1, SBS, Futbol 2, Ring.bg, Eir Sport 2, Canal+ Sport 2 Afrique, PremiumSport 2 HD, PPTV Sport China, Digi Sport 5, OLL.tv, beIN Sports Connect Espana, Tivibu Spor 3, Viasat Ultra HD, Sky Sport 3 HD, beIN Sports Arabia 17 HD, Cytavision Sports 2, nc+ GO, Sky Go Deutschland, Sky Sport 1 Switzerland, Sony LIV, Canal+ Sport Online, BT Sport Live, beIN Sports Arabia 2 HD, beIN LaLiga, SportKlub 1 Slovenia, TDM HD, Cosmote Sport 1 HD, Go Sports 2, beIN Sports Connect Australia, SuperSport Maximo, Canal+ Sport, TV3 Sport, Fox Sports Cono Norte, beIN SPORTS CONNECT Arabia, FOX Play Latin America, Klik SPORT, Astro Go, Telekom TV Live, Viaplay Sweden, beIN Sports Connect Indonesia, Sky Sport 3 NZ, Sky Sport 1 HD, Viaplay Norway