They'll be hopeful of a more straightforward encounter against Eddie Howe's side, with fellow title challengers Chelsea and Manchester City both winning at the weekend and the latter also thumping Leeds United 7-0 on Wednesday night.
The visitors arrive at Anfield short on confidence, having picked up just one win this season, a 1-0 victory over fellow relegation rivals Norwich, before falling to a 4-0 defeat against Leicester at the weekend.
With the possibility of a 'circuit breaker' being introduced in the coming days, the hope is the Reds can go out and get the job done to keep pace at the top of the Premier League table.
Roberto Firmino is set to be included in the matchday squad after missing the Reds' previous eight fixtures due to a hamstring injury, with the Brazilian returning to full team training earlier in the week.
Curtis Jones returned for his first session back at Kirkby following an eye issue, but he continues to remain sidelined for selection alongside Adrian, Nathaniel Phillips, Harvey Elliott and Divock Origi.
Diogo Jota started on the bench at the weekend and is likely to start ahead of Firmino, whilst it'll be intriguing to see what other changes Klopp makes, given the festive fixtures coming thick and fast over the next couple of weeks.
Updated: 19:00 (GMT)
Liverpool: Alisson, Alexander-Arnold, Matip, Konate, Robertson, Henderson, Thiago, Oxlade-Chamberlain, Salah, Jota, Mane. Substitutes: Kelleher, Pitaluga, Milner, Keita, Firmino, Minamino, Gomez, Tsimikas, Williams.
Newcastle: Dubravka, Manquillo, Schar, Lascelles, Lewis, Hayden, Shelvey, Murphy, Saint-Maximin, Fraser, Joelinton. Substitutes: Darlow, Clark, Wilson, Ritchie, Hendrick, Almiron, Willock, Gayle, Longstaff.
UK and USA TV Streaming
Liverpool vs Newcastle is available to stream in the United Kingdom on BT Sport 1, which is available on Sky channel 413 and Virgin Media channel 527.
Supporters in the United States can watch the match live on Peacock at 15:00 (ET).
Worldwide TV Streams
For viewers across the world, please refer to the list below for channels showing the game worldwide.
SuperSport 3 Africa, Stod 2 Sport, beIN Sports 1 Indonesia, ESPN Brasil, DAZN Europe, SuperSport 1 Digitalb, Canal+ Sport 2 Afrique, Sportklub 2 Slovenia, TV3+ HD, Optus Sport, Play Sports 1, PPTV Sport China, Canal+ Sport Online, Digi Sport 1, Sky Sports, NTV+ Sport Online, Digiturk Play, Futbol 1, Viasat Ultra HD, beIN SPORTS CONNECT, Movistar TV Futbol, Star Sports Select 2, TSN GO, Hotstar, SuperSport 3 Nigeria, BesTV, Movistar+, Ziggo Sport 14, Sky Sport 3 HD Italia, Cosmote Sport 1 HD, OLL.tv, 620 PLTV, SPS HD, Viaplay Finland, Cytavision Sports 1, SportsNavi Live, Sport TV3, TSN4, TSN5, Citi FM, Spiler TV,Sport 3, Canal+ Sport 2 Poland, Ziggo Sport Select, Diema Sport 2, SFR Sport 1, Setanta Sports Kazakhstan, Flow Sports App, Watch ESPN Brasil, beIN Sports HD 2, Viaplay Denmark, TV2 Sport Premium, SKY Planeta Futbol