Jurgen Klopp's side travel to Madrid as they look for a positive result against Zinedine Zidane's side to take back to Anfield for the return leg next Wednesday.
It's a highly-anticipated clash between two of Europe's heavyweights and the hope is the Reds can do the business in Spain and take one step closer to a semi-final clash against either Chelsea or Porto.
We'll have all the latest throughout the day, including confirmed team news, live social media updates and post-match reaction. We'll also bring you all the latest from the other tie of the night: Man City vs Dortmund.
Liverpool: Alisson, Alexander-Arnold, Phillips, Kabak, Robertson, Fabinho, Wijnaldum, Keita, Mane, Salah, Jota.
Substitutes: Adrian, H. Davies, Thiago, Milner, Firmino, Jones, Oxlade-Chamberlain, Tsimikas, Shaqiri, B. Davies, R. Williams, Cain.
Real Madrid: Courtois, Vázquez, Militão, Nacho, Mendy, Casemiro, Modrić, Kroos, Asensio, Vinícius, Benzema.
Substitutes: Lunin, Altube, Chust, Odriozola, Marcelo, Valverde, Isco, Arribas, Rodrygo, Mariano.
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