The Reds boss makes three changes to his side from the one that beat Newcastle 3-1 at Anfield at the weekend.
There were doubts over Andy Robertson's fitness after the left-back missed training on Monday morning, however he starts in a Reds backline consisting of Trent Alexander-Arnold, Joel Matip and Virgil van Dijk.
Liverpool: Adrian, Alexander-Arnold, Matip, Van Dijk, Robertson, Fabinho, Milner, Henderson, Mane, Salah, Firmino.
Substitutes: Kelleher, Wijnaldum, Lovren, Gomez, Oxlade-Chamberlain, Lallana, Shaqiri.
Napoli: Meret, Di Loreno, Manolas, Koulibaly, Mario Rui, Callejon, Allan, Fabian, Insigne, Lozano, Mertens.
Substitutes: Ospina, Llorente, Elmas, Maksimovic, Zielinski, Ghoulam, Milik.