The boss makes three changes to his starting eleven from the one that beat Chelsea in the UEFA Super Cup final in Istanbul on Wednesday night.
Adrian, who freakishly sustained a swollen ankle against the Blues, has recovered in time and takes his place between the sticks.
Roberto Firmino also starts, joining Mohamed Salah and Sadio Mane in attack. Joe Gomez makes way for Trent Alexander-Arnold, who starts in defence alongside Joel Matip, Virgil van Dijk and Andy Robertson.
Gini Wijnaldum is also restored to the starting eleven, with James Milner and Alex Oxlade-Chamberlain partnering him in midfield. Fabinho and Jordan Henderson are on the bench alongside Adam Lallana, Xherdan Shaqiri and Divock Origi.
Liverpool: Adrian, Alexander-Arnold, Matip, Van Dijk, Robertson, Wijnaldum, Milner, Oxlade-Chamberlain, Mane, Salah, Firmino
Substitutes: Lonergan, Fabinho, Gomez, Henderson, Lallana, Shaqiri, Origi
Southampton: Gunn, Valery, Vestergaard, Bednarek, Yoshida, Bertrand, Romeu, Ward-Prowse, Höjbjerg, Redmond, Adams
Substitutes: Cedric, Ings, Djenepo, Armstrong, Obafemi, Danso, Forster