Having taken a lead at the top of the table at Christmas, the champions now find themselves six points adrift of the top, with a win sorely needed to restore confidence.
Burnley visit Anfield whilst four points away from the relegation zone, but Sean Dyche's side are far from the perfect opponents for the Reds to face given their lack of goalscoring success of late.
Whilst the Clarets don't score often, they seem to have largely shut up shop at the other side of the pitch, having limited their opponents to goal or less since the end of November.
Liverpool could be in for another frustrating night, but it's now or never for the Reds as their title rivals look to steal a march in the title race. The hope is the Reds can put behind their recent woes and return to their fluid best.
Liverpool will continue without the services of Diogo Jota, who remains at least a few weeks away from action after suffering a knee injury at the start of December.
But the Reds could crucially see Joel Matip return to the back-line, with the Cameroonian expected to slot in alongside Fabinho at the back.
With Liverpool struggling for goals of late, it will be intriguing to see whether Klopp mixes things up in attack, with the likes of Alex Oxlade-Chamberlain, Takumi Minamino and Divock Origi all potential alternatives.
Updated: 7pm (GMT)
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Burnley: . Substitutes: .
UK and USA TV Streaming
Liverpool vs Burnley is available to stream in the United Kingdom on Sky Sports. Sky Sports is available in the UK on Sky channel 401 and Virgin Media channel 501.
Supporters in the United States can watch live on NBCSN at 3pm (ET).
Worldwide TV Streaming
For viewers across the world, please refer to the list below for channels showing the game worldwide.
SPS HD, Cytavision Sports HD, Digi Sport 1, beIN Sports Connect Thailand, Stod 2 Sport, VOOsport World 1, SuperSport 1 Digitalb, Setanta Sports Kazakhstan, Sport 3, Match TV Football 1, SKY Go Italia, Flow Sports App, Viaplay Finland, Movistar TV Futbol, beIN Sports HD 2, Ziggo Sport Select, Ssports Live, SuperSport 3 Nigeria, Canal+ NOW, TV3+ HD, Sport TV3, TSN GO, TV2 Sport Premium, SportsNavi Live, Viasat Ultra HD, Canal+ Sport Online, beIN Sports 1 HD, Viasat Football HD, Play Sports 1, Spiler TV, Star Sports Select HD2, Cosmote Sport 1 HD, Now 621, SFR Sport 1, QQ Sports Live, BesTV, Citi FM, Star Sports Select 2, Sportklub 2 Slovenia, Ziggo Sport 14, Cytavision Sports 1, 620 PLTV, Movistar+, TSN5, Sky Sport 3 HD Italia, Futbol 1, LeTV Sports Hong Kong, TSN4, PPTV Sport China, nc+ GO, Canal+ Sport 2 Poland, Diema Sport 2, Optus Sport, Viaplay Denmark.