The champions appear to have put their recent slump behind them following two wins in London in the past week.
The Reds should be in confident mood after the week they've had, which also saw them ease their defensive issues with a double swoop on transfer deadline day.
But Graham Potter's side will feel they can cause an upset and mirror Burnley's win over the Reds in their last Anfield outing, with the visitors beating Tottenham 1-0 at the weekend thanks to a Leandro Trossard strike.
Liverpool remain strong favourites to continue to build their momentum with another three points before a crunch clash against Pep Guardiola's side this weekend.
While the signings of Ben Davies and Ozan Kabak bolster Liverpool's defensive options, it remains to be seen whether Klopp throws either of them in from the off. Jordan Henderson and Nathaniel Phillips remain likely to continue at the back.
Roberto Firmino should come back into the side after starting from the bench against the Hammers but Sadio Mane remains a big doubt. Elsewhere, there could be changes in the middle of the park after three consecutive games with the same midfield trio.
There are strong suggestions Alisson may miss out due to illness, with Caoimhin Kelleher likely to come in between the sticks should those rumours ring true.
Updated: 19:15 (GMT)
Liverpool: . Substitutes: .
Brighton: . Substitutes: .
UK and USA TV Streaming
Liverpool vs Brighton is available to stream in the United Kingdom on BT Sport 1, which is available on Sky channel 413 and Virgin Media channel 527.
Supporters in the United States can watch live on NBCSN at 15:15 (ET).
Worldwide TV Streaming
For viewers across the world, please refer to the list below for channels showing the game worldwide.
Canal+ NOW, Telekom TV Live, Fox Sports 1 Chile, Canal+ Sport, SuperSport 6 Africa, TV6 Sweden, beIN SPORTS CONNECT Arabia, OLL.tv, CCTV 5+ VIP, Telekom Sport 2 Romania, TV3 Sport,Arena Sport 1 Serbia, SONY TEN 1, PPTV Sport China, beIN Sports Arabia 12 HD, Voyo Sport, PremiumSport 2 HD, Super Soccer TV, RTP 1, TSN2, Sky Sport 1 HD, Go Sports 2, beIN LaLiga, SportKlub 1 Slovenia, Fox Sports Cono Sur, nc+ GO, beIN Sports 2 Indonesia, Sky Sport 3 NZ, SBS Live, Canal+ Sport Online, TDM HD, Viaplay Denmark, beIN Sports Connect Espana, beIN Sports Spain, SBS, Canal+ Sport 2 Afrique, Futbol 2, SKY PerfecTV LIVE, Digi Sport 5, Movistar+, Stod 2 Sport, Esporte Interativo 2, Cosmote Sport 1 HD, Klik SPORT, Sport 1 Hungary, Fox Sports Cono Norte,Tring Sport 2, SuperSport Maximo, TeleClub Sport Live, TSN GO, Sky Go Deutschland, Cytavision Sports 2, Sky Sport 3/HD, Match TV Football 1, Proximus 11+, beIN Sports Arabia 2 HD, Astro Go, Armenia TV, Sukachan 1, Premium Play, beIN Sports Arabia 17 HD, beIN Sports Connect Australia, beIN Sports Connect Indonesia, Viasat Ultra HD, Viaplay Finland, Cytavision Live, Viasat Sport, beIN SPORTS 3 Australia, BT Sport Live, Tivibu Spor 3, beIN Sports 2, Eir Sport 2, Viaplay Norway, Arena Sport 1, Sony LIV, Viasat Ultra HD.