The Reds welcome the Portuguese side to Merseyside as they look to consolidate their place as group winners after already securing their place in the knockout stages of the competition.
Jurgen Klopp's side earned a 5-1 win over the visitors in the reverse fixture at the end of September and the hope is Liverpool can put on a similar display in their final home game of the group stage.
We'll have all the latest throughout the day, including confirmed team news, live social media updates, and post-match reaction.
Liverpool: Alisson, N. Williams, Matip, Konate, Tsimikas, Morton, Thiago, Oxlade-Chamberlain, Salah, Minamino, Mane.
Substitutes: Adrian, Kelleher, Fabinho, Van Dijk, Milner, Henderson, Robertson, Origi, Phillips, Alexander-Arnold.
Porto: Costa, Mario, Pepe, Mbemba, Zaidu, Otavio, Uribe, Oliveira, Diaz, Taremi, Evanilson.
Substitutes: Marchesin, Cardoso, Conceicao, Pepe, Grujic, Corona, Manafa, Vitinha, Wendell, Bruno Costa, Martinez, Vieira.
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