The Reds boss makes five changes to the side that drew with Manchester United at the weekend as Mohamed Salah, Naby Keita, James Milner, Alex Oxlade-Chamberlain and Dejan Lovren come into the starting eleven.
Milner and Lovren are expected to come into the back-line as they replace the injured Trent Alexander-Arnold and Joel Matip.
Liverpool: Alisson, Milner, Lovren, Van Dijk, Robertson, Fabinho, Keita, Oxlade-Chamberlain, Mane, Salah, Firmino.
Substitutes: Adrian, Wijnaldum, Gomez, Henderson, Lallana, Brewster, Origi.
Genk: Coucke, Maehle, Cuesta, Lucumi, Uronen, Bongonda, Heynen, Berge, Ito, Samatta, Onuachu.
Substitutes: Vandevoordt, De Norre, Dewaest, Odey, Hrosovsky, Hagi, Ndongala.