Klopp makes five changes to his starting eleven from the one that started against Norwich City on the opening day of the Premier League.
Alex Oxlade-Chamberlain also starts, with the duo joining Mohamed Salah in attack. Gini Wijnaldum makes way for James Milner, who starts in the middle of the park alongside Fabinho and Jordan Henderson.
Liverpool: Adrian, Gomez, Matip, Van Dijk, Robertson, Fabinho, Milner, Henderson, Oxlade-Chamberlain, Mane, Salah
Substitutes: Lonergan, Kelleher, Wijnaldum, Firmino, Lallana, Shaqiri, Brewster, Origi, Hoever, Alexander-Arnold, Elliott
Chelsea: Arrizabalaga, Azpilicueta, Christensen, Zouma, Emerson, Jorginho, Kovacic, Kante, Pulisic, Pedro, Giroud
Substitutes: Caballero, Zappacosta, Rudiger, Tomori, Alonso, Barkley, Mount, Gilmour, Kenedy, Willian, Batshuayi, Abraham