The Reds travel to London, hoping to make amends for their 2-1 loss to Maurizio Sarri's side in the Carabao Cup on Wednesday.
Klopp had made eight changes from the side that beat Southampton 3-0 at Anfield last weekend, with the likes of Simon Mignolet, Nathaniel Clyne, Fabinho and Alberto Moreno getting their first start of the campaign.
The manager makes __ changes for the Reds' second meeting with Chelsea, with the Reds restoring some key players to their line-up.
Liverpool's summer arrivals of Naby Keita, Fabinho and Shaqiri are all on the bench, having started the League Cup tie on Wednesday.
Liverpool: Alisson, Alexander-Arnold, Gomez, Van Dijk, Robertson, Henderson, Milner, Wijnaldum, Mane, Salah, Firmino.
Substitutes: Mignolet, Moreno, Matip, Fabinho, Keita, Shaqiri, Sturridge.
Chelsea: Kepa, Azpilicueta, Luiz, Rudiger, Alonso, Jorginho, Kante, Kovacic, Willian, Giroud, Hazard.
Substitutes: Caballero, Zappacosta, Cahill, Moses, Fabregas, Barkley, Morata.