The Reds are back in action after defeating Tottenham with a last-gasp winner at Anfield on Sunday as they look for another valuable three points.
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Fabinho starts as the deepest midfielder and he is joined by Gini Wijnaldum and Keita in the middle of the park.
Liverpool: Alisson, Alexander-Arnold, Matip, Van Dijk, Robertson, Fabinho, Wijnaldum, Keita, Mane, Salah, Firmino.
Subs: Mignolet, Lovren, Milner, Henderson, Moreno, Shaqiri, Origi.
Southampton: Gunn, Valery, Yoshida, Bednarek, Vestergaard, Bertand, Ward-Prowse, Romeu, Hojberg, Long, Redmond.
Subs: McCarthy, Stephens, Targett, Armstrong, Gallagher, Sims, Austin.