Both sides sit on 19 points at the top of the Premier League table, separated by six goals on goal difference.
Victory for Liverpool will see them top the table heading into the October international break.
Alisson starts in goal, whilst Dejan Lovren returns to the starting eleven in place of Trent Alexander-Arnold. Joe Gomez moves to right-back, whilst Virgil van Dijk and Andy Robertson make up the rest of defence.
Liverpool: Alisson, Gomez, Lovren, Van Dijk, Robertson, Wijnaldum, Milner, Henderson, Mane, Salah, Firmino.
Subs: Mignolet, Fabinho, Keita, Sturridge, Shaqiri, Matip, Alexander-Arnold.
Manchester City: Ederson, Walker, Stones, Laporte, Mendy, Fernandinho, Silva, Bernardo, Mahrez, Sterling, Aguero.
Substitutes: Muric, Danilo, Kompany, Sané, Otamendi, Jesus, Foden.