Liverpool were far from their best a week ago as they fell to a 3-1 defeat in the first leg of their quarter-finals tie against Zinedine Zidane's side.
With a two-goal deficit to overturn without supporters on the Anfield concourse, the cards are stacked against Jurgen Klopp's side, who will be hoping for another famous European night under the lights at home.
While comebacks on the biggest stage are part and parcel of the club, the visitors are undoubtedly favourites to book their place in the semi-finals of the competition and set up a meeting against already-qualified Chelsea.
The Reds will take confidence from the weekend as they finally clinched an Anfield win for the first time in 2021 - beating Aston Villa with a last-minute Trent Alexander-Arnodl winner. But the hosts will be equally buoyed after their El Clasico victory at the weekend.
Liverpool will need to leave it all out on the pitch if they are to do the improbable. The Reds have been here before and defied the odds; it's now time to deliver once more.
Long-term absentees Joe Gomez, Jordan Henderson, Joel Matip and Virgil van Dijk remain out alongside Divock Origi and Caoimhin Kelleher. Curtis Jones is also a doubt after missing the clash at the weekend and training this week.
Klopp opted to keep Thiago out from the off in the first leg and he could do the same again, with James Milner likely to remain in the side for his work-rate in the middle of the park.
Updated: 18:45 (BST)
Liverpool: . Substitutes: .
Real Madrid: . Substitutes: .
UK and USA TV Streaming
Liverpool vs Real Madrid is available to stream in the United Kingdom on Sky Sports, which is available on Sky channel 401 and Virgin Media channel 501.
Supporters in the United States can watch live on Paramount+ at 15:00 (ET).
Worldwide TV Streams
For viewers across the world, please refer to the list below for channels showing the game worldwide.
BesTV, Viaplay Denmark, RMC Sport 1, Viaplay Finland, Astro Supersport, DIGI GO, ESPN2 Andina, Cytavision Sports HD, Canal+ Sport 2 Afrique, SPOTV ON, Flow Sports App, 620 Now Premier League TV, SCTV 17, SportKlub 1 Slovenia, Sky Pacific, Digi Sport 4, Eurosport Romania, Guangdong Sports Channel, Now Player, TV3+ HD, NTV+ Sport Online, SuperSport 3 Africa, PPTV Sport China, ESPN Brasil, beIN Sports 1 Thailand, Now E, Astro Go, Idman TV, SportKlub 1 Serbia, Flow Sports 1, Play Sports 1, 102 (HD) mio Stadium, DAZN, Sport TV2, Setanta Sports Kazakhstan, Spiler1, Star Sports Select HD1, TVPlay Sports, TSN GO, Viaplay Sweden, #Vamos, Hotstar, Bongda TV, S Sport+, Skynet Sports 6, Cytavision Sports 3, GO TV Anywhere, Ssports Live, Stod 2 Sport, Viasat Football HD, TV2 Sumo, Diema Sport 2, SL2G, Ziggo Sport 14, SBS Live, Sky Sport Uno, Blue To Go Video Everywhere, ESPN Play Sur, beIN Sports HD 11, Watch ESPN Brasil, RDS GO, beIN Sports Connect Indonesia, Optus Sport, Match TV Football 1.