The Liverpool boss will hope his players can continue their winning run and carry on the momentum at the start of the season.
With Saturday's reverse fixture to come in the league on Saturday, Klopp has made wholesale changes to the side that beat Southampton on Saturday.
Fabinho will be the Reds' defensive midfielder, partnered with James Milner and Naby Keita, who has seen his minutes reduced in the past few weeks.
Liverpool: Mignolet; Clyne, Matip, Lovren, Moreno; Fabinho, Milner, Keita; Shaqiri, Mane, Sturridge.
Substitutes: Grabara, Gomez, Henderson, Jones, Salah, Firmino, Solanke.
Chelsea: Caballero, Azpilicueta, Christensen, Cahill, Emerson, Fabregas, Kovacic, Barkley, Moses, Morata, Willian.
Substitutes: Bulka, Luiz, Zappacosta, Kante, Jorginho, Hazard, Hudson-Odoi.